来源:《Chinese Herbal Medicines》2019年第01期  作者:Pei Li;Shan-ting Liao;Jun-song Wang;Qian Zhang;Yan Lv;Ming-hua Yang;Ling-yi Kong;
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Pharmacokinetic and NMR metabolomics approach to evaluate therapeutic effect of berberine and Coptidis Rhizoma for sepsis

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Objective: Sepsis, a systemic response to infection, often leads to end-organ dysfunction. Despite its high rates of mortality and morbidity, its pathophysiology is still poorly understood. Coptidis Rhizoma and its main active alkaloid compound, berberine, have been as anti-bacterial and anti-inflammatory drugs used in clinic. The objective of this study was to gain more insights towards understanding the sepsis associated with drug absorption and disposition and treatments of berberine and Copt(本文共计11页)......[继续阅读本文]

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