来源:《Chinese Herbal Medicines》2019年第01期  作者:Jia-ding Guo;Ying-yue Zhang;Yan Huo;Yan-xu Chang;Er-wei Liu;Jia Hao;
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Monitoring unbound warfarin in drug combination therapy by pharmacokinetics and fluorospectrometry

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Objective: Monitoring the unbound drug concentration in blood in combination therapy is necessary,because its concentration determines the efficacy of drug therapy. This study was designed to explore the effect of Dan Hong Injection(DHI) on the unbound warfarin using two approaches including an in vivo pharmacokinetic and in vitro fluorescence studies.Methods: The effect of DHI on the pharmacokinetic properties of the unbound warfarin was investigated by a microdialysis sampling method coupled w(本文共计6页)......[继续阅读本文]

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