来源:《Cell Research》2005年第06期  作者:Raymond A DANIELS,Helen TURLEY,Fiona C KIMBERLEY,Juthathip MONGKOLSAPAYA,Paul CH’EN,Francesco PEZZELLA,Gavin R SCREATON
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Expression of TRAIL and TRAIL receptors in normal and malignant tissues

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INTRODUCTION TRAIL is a type II transmembrane protein and a memberof the TNF family [1, 2]. Preliminary Northern blottinganalyses showed that TRAIL is expressed on a wide rangeof tissues [2]. TRAIL activates apoptosis through the deathreceptors TR1 (TRAILR-1, DR4) and TR2 (TRAILR-2,DR5, TRICK2, KILLER), which are members of theTNFR superfamily [3–6]. TRAIL also binds two othermembrane bound receptors, TR3 and TR4, which bearsubstantial sequence homology in the extracellular domainto TR1 and TR2.(本文共计9页)......[继续阅读本文]

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