来源:《Cell Research》2005年第06期  作者:Tyler ZARUBIN
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Identification of eight genes that are potentially involved in tamoxifen sensitivity in breast cancer cells

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INTRODUCTION Tamoxifen is one of the most widely used drugs in thetreatment of estrogen-receptor α (ER)-positive breastcancer. Used for over twenty years, tamoxifen has beenshown to greatly prolong disease-free survival and in-duce remission in over half of patients with estrogen re-ceptor positive metastatic disease [1]. In addition to beingused as a treatment for breast cancer, tamoxifen has alsobeen shown to be a preventative agent for hormone-de-pendent breast cancer and it is thought that a(本文共计8页)......[继续阅读本文]

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