来源:《Cell Research》2007年第07期  作者:
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The magic of four: induction of pluripotent stem cells from somatic cells by Oct4, Sox2, Myc and Klf4

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The developmental process from a fertilized egg to agrown adult is programmed with remarkable accuracy.While the genetic information of the fertilized egg and itsdescendent somatic cells are the same, it is the selectiveexpressions of the same genome that give rise to the 200or so different cell types in an adult. The differentiatedstates of these adult cells are maintained epigenetically,presumably through the modification of chromatins and theassociated histones. In higher mammals, it was (本文共计3页)

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