来源:《Cell Research》2007年第07期  作者:Elizabeth S Poole;David J Young;Marjan E Askarian-Amiri;Debbie-Jane G Scarlett;Warren P Tate;
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Accommodating the bacterial decoding release factor as an alien protein among the RNAs at the active site of the ribosome

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The decoding release factor (RF) triggers termination of protein synthesis by functionally mimicking a tRNA to spanthe decoding centre and the peptidyl transferase centre (PTC) of the ribosome. Structurally, it must fit into a site craftedfor a tRNA and surrounded by five other RNAs, namely the adjacent peptidyl tRNA carrying the completed polypeptide,the mRNA and the three rRNAs. This is achieved by extending a structural domain from the body of the protein thatresults in a critical conform(本文共计17页)

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