来源:《Cell Research》2007年第07期  作者:
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Downregulation of CD4+CD25+ regulatory T cells may underlie enhanced Th1 immunity caused by immunization with activated autologous T cells

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Regulatory T cells (Treg) play important roles in immune system homeostasis, and may also be involved in tumorimmunotolerance by suppressing Th1 immune response which is involved in anti-tumor immunity. We have previouslyreported that immunization with attenuated activated autologous T cells leads to enhanced anti-tumor immunity andupregulated Th1 responses in vivo. However, the underlying molecular mechanisms are not well understood. Here weshow that Treg function was significantly downregu(本文共计11页)

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