来源:《Virologica Sinica》2018年第05期  作者:Madina Mahesutihan;Weinan Zheng;Liang Cui;Yun Li;Pengtao Jiao;Wenxian Yang;Wei Liu;Jing Li;Wenhui Fan;Limin Yang;Wenjun Liu;Lei Sun;
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CypA Regulates AIP4-Mediated M1 Ubiquitination of Influenza A Virus

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Cyclophilin A (CypA) is a peptidyl-prolyl cis/trans isomerase that interacts with the matrix protein (M1) of influenza A virus (IAV) and restricts virus replication by regulating the ubiquitin–proteasome-mediated degradation of M1. However,the mechanism by which CypA regulates M1 ubiquitination remains unknown. In this study, we reported that E3 ubiquitin ligase AIP4 promoted K48-linked ubiquitination of M1 at K102 and K104, and accelerated ubiquitin–proteasome-mediated degradation of M1. The re(本文共计9页)......[继续阅读本文]

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